Most people use medicines or pills during a hangover. Aspirin and Ibuprofen may reduce headache and muscular pain, but they shouldn't be used if you're experiencing abdominal pain or nausea. These medicines are gastric irritants and can compound gastrointestinal hangover symptoms.

In addition, Tylenol should not be taken for a hangover, because alcohol's metabolism only enhances the acetaminophen's toxicity.

By all means, use an over-the-counter painkiller such as Aspirin or Ibuprofen to help ease the headache, but keep one thing in mind - take the pills on the morning after and not before going to bed when the alcohol is still in high volume in your system.